Clinical effect of platelet rich plasma in the treatment of periodontal intrabony defects. Systematic review and meta-analysis


  • Heber Arbildo Escuela de Odontología, Universidad Particular de Chiclayo. Chiclayo, Perú.
  • Luis Gamarra 4Escuela de Estomatología, Universidad Privada Antonio Guillermo Urrelu. Cajamarca, Perú
  • Sandra Rojas Facultad de Estomatología, Universidad Nacional de Trujillo. Trujillo, Perú
  • Edward Infantes Escuela de Estomatología, Universidad Señor de Sipán. Chiclayo, Perú


Palabras clave:

Platelet-rich plasma, periodontitis, review, meta-analysis


Introduction: One of the consequences of periodontitis is periodontal intrabony defects (PID). Various biomaterials have been used for its treatment, but there is still no biomaterial considered as the gold standard. Current research is focused on the use of platelet-rich plasma (PRP) for the treatment of PID. Objective: To determine the clinical effect of PRP in the treatment of PID through a systematic review with meta-analysis. Materials and Methods: A literature search was conducted until February 2017 in the biomedical databases: Pubmed, Embase, Scielo, Science Direct, SIGLE, LILACS, IBECS, and the Cochrane Central Register of Clinical Trials. The criteria for the selection of the studies, which were randomized clinical trials, were the following: articles or papers published in the last 5 years, reporting clinical effects, with a follow-up time equal to or greater than 6 months, and a sample size equal to or greater than 10 patients reporting the use of PRP as a treatment for PID. The methodological quality of the
studies was analyzed using the Cochrane Handbook of Systematic Reviews of Interventions as a reference. Results: The search strategy yielded nine articles reporting a reduction in probing depth and gingival recession, and an increase in clinical insertion level when using PRP alone or in combination
with another biomaterial.


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Cómo citar

Arbildo H, Gamarra L, Rojas S, Infantes E. Clinical effect of platelet rich plasma in the treatment of periodontal intrabony defects. Systematic review and meta-analysis. J Oral Res [Internet]. 3 de julio de 2019 [citado 25 de febrero de 2024];6(4):97-104. Disponible en: