Clinical effect of platelet rich fibrin in the treatment of periodontal intrabony defects. Systematic review and meta-analysis


  • Heber Arbildo 1Escuela de Odontología, Universidad Particular de Chiclayo. Chiclayo, Perú
  • Luis Gamarra 4Escuela de Estomatología, Universidad Privada Antonio Guillermo Urrelu. Cajamarca, Perú
  • Sandra Rojas Facultad de Estomatología, Universidad Nacional de Trujillo. Trujillo, Perú
  • Edward Infantes Escuela de Estomatología, Universidad Señor de Sipán. Chiclayo, Perú
  • Cesar Lamas 7Escuela de Odontología, Universidad Católica los Ángeles de Chimbote. Chimbote, Perú
  • Hernán Vásquez 8Facultad de Odontología, Universidad San Martín de Porres. Lima, Perú


Palabras clave:

Platelet rich fibrin, periodontitis, review, meta analysis


Background: There is currently no gold standard biomaterial for the treatment of periodontal intrabony defects (PIDs). One of the current options is the use of platelet-rich fibrin (PRF). Objective: To determine the clinical effect of PRF in the treatment of PID through a systematic review and meta-analysis. Materials and Methods: A literature search was conducted up to February 2017 in the following biomedical databases: Pubmed, Embase, Scielo, Science Direct, SIGLE, LILACS and in the Cochrane Central Register of Clinical Trials. The selection criteria included: randomized clinical trials published in the last 5 years, reporting clinical effects (probing depth, clinical insertion level or gingival recession), with a follow-up time equal to or greater than 6 months, and sample size larger than or equal to 10 patients reporting the use of PRF as a treatment for PID. The methodological quality of the studies was analyzed using the Cochrane Handbook of Systematic Reviews of Interventions as a reference. Results: The search strategy yielded 20 articles. A reduction in probing depth and an increase in clinical insertion level or a reduction in gingival recession is reported, when using PRF alone or in combination with another biomaterial or substance that stimulates tissue regeneration.


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Cómo citar

Arbildo, H., Gamarra, L., Rojas, S., Infantes, E., Lamas, C., & Vásquez, H. (2019). Clinical effect of platelet rich fibrin in the treatment of periodontal intrabony defects. Systematic review and meta-analysis. Journal of Oral Research, 6(5), 127-135.