Efecto regenerador del ácido hialurónico en defectos óseos circunferenciales en ratas albinas Wistar.

Autores/as

  • Cecilia Bueno-Beltrán Escuela Profesional de Estomatología, Universidad Alas Peruanas, Perú.
  • Yerlin Budiel-Salguero Escuela Profesional de Estomatología, Universidad Alas Peruanas, Perú.
  • Sandro Palacios-Bustamante Escuela Profesional de Estomatología, Universidad Alas Peruanas, Perú.
  • Carlos Neyra-Rivera Escuela de Posgrado, Universidad Norbert Wiener, Perú.

DOI:

https://doi.org/10.17126/%25x

Palabras clave:

Ácido hialurónico, regeneración ósea, cicatrización de heridas, matriz ósea, ratas wistar, materiales biocompatibles

Resumen

Objetivo: Determinar el efecto regenerador del ácido hialurónico en defectos óseos circunferenciales en ratas albinas Wista. Material y Métodos: Se diseñó un estudio de tipo experimental y se trabajó con 15 ratas albinas Wistar (todas macho) de 4 meses de edad y con un peso entre 250 a 350 gr. Se crearon en todas 2 defectos óseos circunferenciales de 3mm de diámetro y 0.8 mm de profundidad en la calota del hueso parietal (a ambos lados de la línea media). Un defecto fue rellenado con una matriz ósea desmineralizada (grupo control); mientras que el otro defecto fue rellenado con la combinación de una matriz ósea desmineralizada más el ácido hialurónico (grupo experimental). Se realizó la eutanasia a 05 ratas de experimentación a los 30, 60 y 90 días postquirúrgicos y se evaluaron histológicamente siguiendo los parámetros propuestos por Heiple. Resultados: El grupo experimental presentó un mejor grado de regeneración ósea en los 30 y 60 días postoperatorios. Conclusiones: El ácido hialurónico es eficaz en la regeneración ósea de defectos óseos circunferenciales.

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Citas

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Publicado

2021-08-31

Cómo citar

Bueno-Beltrán, C. ., Budiel-Salguero, Y. ., Palacios-Bustamante, S. ., & Neyra-Rivera, C. . (2021). Efecto regenerador del ácido hialurónico en defectos óseos circunferenciales en ratas albinas Wistar . Journal of Oral Research, 10(4), 1-11. https://doi.org/10.17126/%x

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