Propiedades físicas-mecánicas-biológicas del poli (metilmetacrilato) enriquecido con óxido de grafeno como potencial biomaterial.

Autores/as

  • René García-Contreras Escuela Nacional de Estudios Superiores (ENES) Unidad León, Universidad Nacional Autónoma de México (UNAM), León, Gto., México; Osforma, Los Algodones, B.C., México.
  • Héctor Guzmán-Juárez Osforma, Los Algodones, B.C., México
  • Daniel López-Ramos TPD Práctica privada.
  • Carlos Alvarez-Gayosso Osforma, Los Algodones, B.C., México; DEPEI-UNAM, Laboratorio Materiales Dentales, Cd. México, México.

DOI:

https://doi.org/10.17126/%25x

Resumen

Objective: To determine the cytotoxicity and effects of graphene oxide (GO) on cellular proliferation of gingival-fibroblasts, pulpdental cells and human osteoblasts in culture, and to determine the physical, mechanical and biological properties of poly (methyl methacrylate) (PMMA) enriched with GO. Material and Methods: T he G O w as c haracterized with SEM. Cytotoxicity and cell proliferation were determined by the MTT bioassay. The physical-mechanical tests (flexural strength and elastic  modulus) were carried out with a universal testing machine. Sorption and solubility were determined by weighing before and after drying and immersion in water. Porosity was evaluated by visual inspection. Data were analyzed with Student's t-test and Tukey's post-hoc ANOVA. Results: The GO has a heterogeneous morphology and a particle size of 66.67±64.76 ?m. GO has a slight to no-cytotoxicity (>50-75% viability) at 1-30 days, and at 24 hours incubation of PMMA with GO significantly stimulates osteoblasts (45±8%, p<0.01). The physical and mechanical properties of PMMA with GO increase considerably without altering sorption, solubility and porosity. Conclusion: GO alone or with PMMA has an acceptable biocompatibility, could contribute to cell proliferation, cell regeneration and improve the physical-mechanical properties of PMMA.

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Publicado

2021-04-30

Cómo citar

1.
García-Contreras R, Guzmán-Juárez H, López-Ramos D, Alvarez-Gayosso C. Propiedades físicas-mecánicas-biológicas del poli (metilmetacrilato) enriquecido con óxido de grafeno como potencial biomaterial. J Oral Res [Internet]. 30 de abril de 2021 [citado 22 de septiembre de 2023];10(2):1-9. Disponible en: http://revistas.udec.cl/index.php/journal_of_oral_research/article/view/5835

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