Papel prospectivo del VEGF en la asociación entre periodontitis y psoriasis: Revisión sistemática exploratoria
DOI:
https://doi.org/10.17126/joralres.2024.023Resumen
Introducción: Periodontitis y psoriasis se asocian en la literatura. La angiogénesis mediada por factores de crecimiento endotelial vascular (VEGF) es un mecanismo común a ambas patologías. Es posible que el VEGF participe en la asociación entre ambas enfermedades. Objetivo: Resumir sistemáticamente la evidencia disponible con respecto a la plausibilidad de la participación del VEGF en la asociación periodontitis/psoriasis.
Materiales y Métodos: Revisión sistemática exploratoria. Se seleccionaron palabras clave y criterios para una búsqueda comprensiva en PubMed. Solo se incluyeron estudios en humanos publicados en los últimos 7 años. Publicaciones en idiomas que no fuesen inglés/español fueron excluidas. Dos revisores independientes realizaron el cribado y la tabulación de datos.
Resultado: Se incluyeron doce estudios. Sus principales enfoques fueron: Niveles de VEGF en el fluido crevicular gingival (FCG) de pacientes con periodontitis (n=7), niveles de VEGF en el suero de pacientes con periodontitis (n=3) y niveles de VEGF en el suero de pacientes con psoriasis (n=3). No se encontraron estudios sobre los niveles de VEGF en el FCG de pacientes con psoriasis. Ningún estudio incluyó personas con periodontitis y psoriasis concurrentes.
Conclusión: La evidencia muestra niveles aumentados de VEGF en el FCG y suero de pacientes con periodontitis, y niveles aumentados de VEGF en el suero de sujetos con psoriasis. Si bien el VEGF participa de la patogénesis de ambas enfermedades, existe un vacío de conocimiento en relación con sus niveles en el FCG de pacientes psoriásicos. Los mecanismos exactos y rol del VEGF en la asociación periodontitis/psoriasis son desconocidos.
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