@article{Mezadri_Ortolan_2019, title={Osteogenic potential of different chalcones in an in vivo model: A preliminary study}, volume={6}, url={https://revistas.udec.cl/index.php/journal_of_oral_research/article/view/929}, DOI={10.17126/%x}, abstractNote={<p>To evaluate the osteogenic potential of chalcones using the rat critical size calvarial defect. Methods. The chalcones were synthesized from acetophenone following the Claisen-Schmidt aldol condensation method by varying the substituted benzaldehydes (3,4-Cl; 4-Cl; 4-CH3; 4-OCH3, H). The five chalcone molecules were evaluated in three concentrations (1%, 5% and 10%) in comparison to control and vehicle (Vaseline) groups. The results of the remaining wound areas were calculated statistically by the ANOVA method followed by the Student-Newman-Keuls test and the histological sections were analyzed qualitatively by light microscopy. Results. All molecules at 10% concentration showed significant bone closure compared to the control, vehicle and chalcone groups at 1% concentration (p&lt;0.01). Active osteoblasts were observed on the repair surfaces in all groups treated with chalcones. Treatment with the C5 molecule at concentration of a 10% resulted in greater bone neoformation compared to the other molecules, with features of secondary bone observed.</p>}, number={8}, journal={Journal of Oral Research}, author={Mezadri, Telmo José and Ortolan, Xana Raquel}, year={2019}, month={jul.}, pages={209-215} }