@article{Arbildo_Gamarra_Rojas_Infantes_Lamas_Vásquez_2019, title={Clinical effect of platelet rich fibrin in the treatment of periodontal intrabony defects. Systematic review and meta-analysis}, volume={6}, url={https://revistas.udec.cl/index.php/journal_of_oral_research/article/view/906}, DOI={10.17126/%x}, abstractNote={<p>Background: There is currently no gold standard biomaterial for the treatment of periodontal intrabony defects (PIDs). One of the current options is the use of platelet-rich fibrin (PRF). Objective: To determine the clinical effect of PRF in the treatment of PID through a systematic review and meta-analysis.&nbsp;Materials and Methods: A literature search was conducted up to February 2017 in the following biomedical databases: Pubmed, Embase, Scielo, Science Direct, SIGLE, LILACS and in the Cochrane Central Register of Clinical Trials. The selection criteria included: randomized clinical trials published in the last 5 years, reporting clinical effects (probing depth, clinical insertion level or gingival recession), with a follow-up time equal to or greater than 6 months, and sample size larger than or equal to 10 patients reporting the use of PRF as a treatment for PID. The methodological quality of the studies was analyzed using the Cochrane Handbook of Systematic Reviews of Interventions as a reference. Results: The&nbsp;search strategy yielded 20 articles. A reduction in probing depth and an increase in clinical insertion level or a reduction in gingival recession is reported, when using PRF alone or in combination with another biomaterial or substance that stimulates tissue regeneration.</p>}, number={5}, journal={Journal of Oral Research}, author={Arbildo, Heber and Gamarra, Luis and Rojas, Sandra and Infantes, Edward and Lamas, Cesar and Vásquez, Hernán}, year={2019}, month={jul.}, pages={127-135} }